NMN or Nicotinamide mononucleotide is formed as a result of a reaction between a phosphate group and nucleoside consisting of ribose and nucleotide. Until a few years ago, NMN was only known for its intermediary activity in NAD+ biosynthesis. However, recent studies have been able to prove NMN’s many benefits. For instance, NMN can be effective in cardiac and cerebral ischemia, Alzheimer’s, Diabetes, obesity, and so on. Head over to https://www.phcoker.com/product/1094-61-7/ to know more.
NMN: Pharmacological Activities
NMN can work wonders in modern-day pharmacology. Here is how.
- Ischemia-Reperfusion Injury
Ischemic events can lead to a decrease in oxygen and ATP levels in cardiac muscle cells. These cardiac muscle cells will then undergo necrosis. The process of resupplying blood to tissues that have undergone Ischemia is known as Reperfusion. This can result in calcium overload due to microvascular injury. Therefore, Ischemia followed by Reperfusion can be dangerous for humans. NMN in humans can reverse this condition.
- Alzheimer’s Disease
Underlying causes of this neurological disease include morphological abnormalities of mitochondria, decrease in oxygen consumption rates, and NAD+ content. Researchers have looked into this extensively, and their explanation has shown that NMN can treat these underlying causes.
- Intracerebral Haemorrhage
ICN is one of the leading causes behind strokes in humans. Firstly, it can cause mechanical damage to neighbouring tissues via hematoma formation. Secondly, it can also cause damage via pathological alterations. As per research, NMN can be used to treat this disease.
Insulin resistance is one of the main features of Type 2 Diabetes. It happens as a result of oxidative stress, augmented inflammatory response, and impaired lipid metabolism. NMN can help treat diabetes in humans.
Nicotinamide riboside has a lot of other benefits. It promotes healthy ageing, lowers risks of heart diseases, and can even aid weight loss.
NMN: Side Effects
- Lack of Clinical Studies – In certain studies, consuming 1,000-2,000 mg of NMN did not result in any side effects. Similarly, animals consuming 300 mg per kg body weight of NMN everyday did not exhibit any side effects either. However, most of these studies were very short in duration, and participants were very less in number. Before administering NMN to humans for the treatment of diseases, more robust studies must be conducted.
- Mild to Moderate Side Effects – Some humans experienced side effects in the form of nausea, fatigue, headaches, diarrhea, and indigestion.
- Pregnant women and Breastfeeding Mothers – Long term effects of NMN in humans is unknown. Hence, pregnant women and breastfeeding mothers are advised against consuming NMN as dietary supplements.
To Sum Up
Researchers need to conduct robust experiments with regard to NMN before administering it to humans in the future. After all, NMN might prove effective in treating a wide range of diseases. Most NMN powder manufacturers recommend not more than 250-300 mg of NMN per day. Research has shown that dietary supplement can be a consumer in small amounts. But, long term effects are still unknown.